Current Issue : April-June Volume : 2020 Issue Number : 2 Articles : 1 Articles
The present study is an attempt to preparation and evaluation of hollow microballoons of lopinavir by using ethyl cellulose and eudragit S-100 as polymers for treating HIV. There were ten different formulations FS1-FS5 and FN1-FN5 were prepared by the solvent evaporation method and non-aqueous solvent evaporation method respectively. Changing the polymer concentration ratio will significantly affect the in-vitro drug release. The formulated hollow microballoons were evaluated for percentage yield, scanning electron microscopy, particle size, in-vitro release and in-vitro buoyancy. Among ten formulations FS-4 and FN-3 was obtained as ideal formulation. The drug and physical mixture were characterized by FTIR their results indicates that there was no interaction between the drug and polymer. The short term stability studies on the optimized formulations indicate that there are no physical or chemical changes in the formulations during the 3 month study period time. According to the data obtained from lopinavir hollow microballoons in-vitro release showing sustained release over a period of 12 hrs. Comparative study of two different methods shows that solvent evaporation method is a better alternative to non-aqueous solvent evaporation method....
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